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This environment is largely unknown and may contain counter-ions, lipid molecules and a membrane surface as well as receptor and water. Dntg Confonnations and Electron Interactions 43 For any study, theoretical or experimental, the only way to proceed to an understanding of the essentials for productive binding is to study a series of physically and chemically similar molecules with a variety of biological potencies and to concentrate on differences between members of the series, assuming that the receptor environment produces a constant effect.

W. and Tong, H. K. J. Am. Chem. , 78,4896 Ham, N. , Casy, A. F. and Ison, R. R. J. Med. , 16,470 Hansch, C. Acc. Chem. , 2, 232 Hansch,C. J. Med. , Deutsch, E. W. and Smith, R. N. J. Am. Chem. , Leo, A. and Nikaitani, D. J. Org. , Unger, S. , Kim, K. , Nikaitani, D. and Lien, E. J. (1973a). J. Med. , Unger, S. H. and Forsythe, A. B. J. Med. , 16, 1217 Herlem, M. (1965). Bull. Soc. Chim. France, 3329 Higuchi, T. and Davis, S. S. J. Pharm. , 59,1376 Hine, J. and Mookerjee, P. K. J. Org. , 40, 292 Hirt, R.

K. J. Am. Chem. , 78,4896 Ham, N. , Casy, A. F. and Ison, R. R. J. Med. , 16,470 Hansch, C. Acc. Chem. , 2, 232 Hansch,C. J. Med. , Deutsch, E. W. and Smith, R. N. J. Am. Chem. , Leo, A. and Nikaitani, D. J. Org. , Unger, S. , Kim, K. , Nikaitani, D. and Lien, E. J. (1973a). J. Med. , Unger, S. H. and Forsythe, A. B. J. Med. , 16, 1217 Herlem, M. (1965). Bull. Soc. Chim. France, 3329 Higuchi, T. and Davis, S. S. J. Pharm. , 59,1376 Hine, J. and Mookerjee, P. K. J. Org. , 40, 292 Hirt, R. , Schmitt, R.

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