By Daniel Silva

A grasp author of espionage" (Cincinnati Enquirer), Daniel Silva makes his Signet debut along with his such a lot acclaimed novel to date... Framed for the homicide of a millionaire banker, Israeli secret agent by means of alternate and paintings restorer by means of choice, Gabriel Allon, must struggle for his life-against an murderer he himself helped teach.

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Additional resources for The English Assassin (Gabriel Allon, Book 2)

Example text

The other area of interest has been cutaneous T-cell lymphoma. viewed. Interferon as a Single Agent The first studies in lymphoma used IFN-alpha obtained from 'buffy coats', at an empirical, relatively low dose, which had been shown to be consistent with a normal, ambulatory lifestyle, as determined in the Scandinavian osteogenicsarcoma studies [1]. In approximately one third of patients with follicular lymphoma in whom conventional therapy had failed, objective responses (usually partial) were observed and the side-effects were, in general, tolerable [10-16,18].

001 41 20 NS 15 21 NS 18 Treatment groups Study group All pts Stage II Stage III No treatment vs a-IFN alone No. pts. 50 86 MP vs MP + a-IFN 26 MP vs MP + a-IFN 34 43 43 NS = not significant maintenance therapy [45]. The results of 3 studies using alpha-IFN as maintenance therapy are shown in Table 5. A significantly longer response duration time and survival was found for patients receiving IFN therapy. A similar study is conducted by the Myeloma Group of Western Sweden [46]. Also in this study a significant prolongation of the response duration time was found.

Blood 1986 (67):15421549 26 Osterborg A, Nilsson B, Bjorkholm M, Holm G and Mellstedt H: Natural killer cell activity in monoclonal gammopathies: Relation to disease activity. Eur J Haematol1990 (45):153-157 27 Einhorn S, Ahre A, Blomgren H et al: Interferon and natural killer activity in multiple myeloma. Lack of correlation between interferon induced enhancement of natural killer activity and clinical The Mechanisms of Action and the Role of Alpha Interferon in the Therapy of Myeloma 28 29 30 31 32 33 34 35 36 response to human interferon-alpha.

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