By James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith

History, Wild Mice, and Genetics, the 1st quantity within the 4 quantity set, The Mouse in Biomedical Research, presents information regarding the historical past, biology and genomics of the laboratory mouse (Mus musculus), in addition to simple details on upkeep and use of mouse shares. Mouse origins and relationships are lined in chapters on background, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are coated in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular association of the mouse genome. upkeep of laboratory mice is defined in chapters on breeding platforms for numerous sorts of lines and shares and genetic tracking. Use of the mouse as a version method for easy biomedical examine is defined in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. the data in quantity 1 serves as a primer for scientists new to the sphere of mouse study.

Show description

Read Online or Download The Mouse in Biomedical Research. History, Wild Mice, and Genetics PDF

Similar methodology & statistics books

How to Research

Examine innovations to discover the data you wish This revised 3rd version offers necessary suggestions on how to gather facts, write proposals, and make displays. providing you step by step suggestions for the most productive and concentrated study in class or paintings tasks, how you can study comprises hands-on routines that construct up talents and increase examine strategies helpful for any venture, in any box.

Teilhard's vision of the past: the making of a method

The Phenomenon of guy, by way of Pierre Teilhard de Chardin, has been characterised as metaphysics, poetry, and mysticism-virtually every thing other than what its writer claimed it used to be: a only medical mmoir. Professor O'Connell right here follows up on a nest of clues, exposed first in an early unpublished essay, then within the sequence of essays contained largely within the imaginative and prescient of the previous.

Gene Transfer and Expression: A Laboratory Manual

A realistic handbook of protocols for attaining expression of overseas genes in mammalian cells. It comprises a few very new suggestions akin to PCR-based expression. the writer offers a theoretical advent to the protocols and compares the strengths and weaknesses.

The economic laws of scientific research

'Dr Kealey's courageous, wonderful and discovered ebook makes a robust case for his unpopular perspectives. It needs to provide pause to any open-minded pupil of technological know-how coverage. ' - R. C. O. Matthews 'Not given that J. D. Bernal has a practicing British scientist challenged traditional arguments concerning the investment of technological know-how so initially, and so powerfully.

Additional info for The Mouse in Biomedical Research. History, Wild Mice, and Genetics

Sample text

Flow of mitochondrial DNA across a species boundary. Proc. Natl. Acad. Sci. U S A 80, 2290-2294. , Ivanyi, P. (1975). ). Genet. , Camb. 24, 189-206. , Loudovamickova, M. (1991). Genetic mapping of the t-complex region on mouse chromosome 17 including the hybrid sterility-1 gene. Mamm. Genome 1, 84-91. , Thaler, L. (1984). Clonal divergence of mitochondrial DNA versus population evolution of nuclear genome. Evol. Theory 7, 81-90. Frisman, L. , Korobitsina, K. , Yakimenko, L. V. (1990). R. house mice: Electrophoretic study of proteins.

73, 3628-3632. Keeler, C. (1978). How it all began. In Origins of inbred mice, 179-193. Academic Press, New York. Klenova, E. , Morse, H. C. , Lobanenkov, V. V. (2002). The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Sem. Cancer Biol. 49, 1-16. , Milstein, C. (1975). Continuous cultures of fused cells secreting antibodies of predefined specificity. Nature 256, 495-497. Kozak, C. , Hartley, J. , Morse, H. C. (1984). Laboratory and wild-derived mice with multiple loci for production of xenotropic murine leukemia virus.

Musculus, and the M. spicilegus/M, macedonicus clade (*) are also depicted. Comparative data from nuclear genes suggest that M. spretus is most closely related to an M. spicilegus/M, macedonicus clade, whereas the mitochondrial data place M. spretus as basal to both the M. spicilegus/M, macedonicus clade and the M. musculus complex. Alternative arrangements for the Asian species, M. cervicolor, M. cookii, and M. caroli (**) include M. cervicolor/M, cookii as sister taxa, with M. caroli, as basal or M.

Download PDF sample

Rated 4.03 of 5 – based on 24 votes