By James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith
History, Wild Mice, and Genetics, the 1st quantity within the 4 quantity set, The Mouse in Biomedical Research, presents information regarding the historical past, biology and genomics of the laboratory mouse (Mus musculus), in addition to simple details on upkeep and use of mouse shares. Mouse origins and relationships are lined in chapters on background, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are coated in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular association of the mouse genome. upkeep of laboratory mice is defined in chapters on breeding platforms for numerous sorts of lines and shares and genetic tracking. Use of the mouse as a version method for easy biomedical examine is defined in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. the data in quantity 1 serves as a primer for scientists new to the sphere of mouse study.
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Flow of mitochondrial DNA across a species boundary. Proc. Natl. Acad. Sci. U S A 80, 2290-2294. , Ivanyi, P. (1975). ). Genet. , Camb. 24, 189-206. , Loudovamickova, M. (1991). Genetic mapping of the t-complex region on mouse chromosome 17 including the hybrid sterility-1 gene. Mamm. Genome 1, 84-91. , Thaler, L. (1984). Clonal divergence of mitochondrial DNA versus population evolution of nuclear genome. Evol. Theory 7, 81-90. Frisman, L. , Korobitsina, K. , Yakimenko, L. V. (1990). R. house mice: Electrophoretic study of proteins.
73, 3628-3632. Keeler, C. (1978). How it all began. In Origins of inbred mice, 179-193. Academic Press, New York. Klenova, E. , Morse, H. C. , Lobanenkov, V. V. (2002). The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Sem. Cancer Biol. 49, 1-16. , Milstein, C. (1975). Continuous cultures of fused cells secreting antibodies of predefined specificity. Nature 256, 495-497. Kozak, C. , Hartley, J. , Morse, H. C. (1984). Laboratory and wild-derived mice with multiple loci for production of xenotropic murine leukemia virus.
Musculus, and the M. spicilegus/M, macedonicus clade (*) are also depicted. Comparative data from nuclear genes suggest that M. spretus is most closely related to an M. spicilegus/M, macedonicus clade, whereas the mitochondrial data place M. spretus as basal to both the M. spicilegus/M, macedonicus clade and the M. musculus complex. Alternative arrangements for the Asian species, M. cervicolor, M. cookii, and M. caroli (**) include M. cervicolor/M, cookii as sister taxa, with M. caroli, as basal or M.