By Richard Price

A teenage gang comes of age within the Sixties Bronx. Written whilst the writer was once twenty-four, this tale used to be the foundation for an enormous function movie.

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Kessler, S. Helmling, J. P. O'Connor, and C. Moore, MoL Cell Biol. 19, 7733 . 70D. Richter, E. Niegemann, and M. Brendel, Mol. Gen. Genet. 231, 194 (1992). 71 p. j. Preker, M. Ohnacker, L. Minvielle-Sebastia, and W. Keller, EMBO J. 16, 4727 (1997). 72G. Schreiber, C. Frisch, and A. R. Fersht, J. Mol. Biol. 270, 111 (1997). 73j. j. Beintemaand R. G. Kleineidam, Cell. Mol. Life Sci. 54, 825 (1998). [l ] N A T U R A L CLASSIFICATION OF R I B O N U C L E A S E S 2. a Helix-Grip Fold. A small number of proteins of the START domain superfam ily that possess the Helix-Grip fold 74 appear to possess ribonuclease activity.

Huang. B. Li, M. D. Gray, J. Oshima, A. S. Kamath-Locb. M. Fry. and L A. Loeb. N~¢t ( k ' , , ~ 211, 114 (1998t. 4~' V. Morozov, A. R. Mushegian. E. V. Koonin. and P. Bork, 1/et~ds/lio

S. Han, L, A. Rajman. and S. T. I Bu, retool. 181, 60tJS ( 1999L 7s A. Komberg, N. N. Rao, and D. Ault-Riche, Atom. Rev. Bio¢4u,m. 68, 89 (199t~). ~'~ E. V Koonin. Y. 1. Wolf, and L. Aravind. Adv. Protein C/win S4, 245 (200(I}. 24 RIBONUCLEASE CLASSIFICATION AND REVIEW [ 1] appear to be utilized in other roles such as pathogen response and pollen selfincompatibility. 80 KEM1/RAT1 Fold. The KEM1/RAT1 superfamily is defined by a large composite module that is conserved in at least the crown-group eukaryotes.

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